Secondary lymphoid organs: responding to genetic and environmental cues in ontogeny and the immune response.

Ontogeny and the Immune Response Genetic and Environmental Cues in Secondary Lymphoid Organs: Responding to

Effect of Dietary Organic Zinc and Prebiotic on Productive Performance and Immune Response of Growing Quails

The aim of the present study was to investigate the possibility of improvingproductive performance and immunity of growing Japanese quailreared during summer in Egypt by supplementing the diets with organic zinc (Bioplex zinc) and prebiotic (mannan oligosaccharides). Diets were a basal diet or the basal diet supplemented with 20 mg Bioplex zinc (3.0 mg Zn) (Zn1), 40 mg Bioplex zinc (6.0 mg Zn) ...

Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs.

The allospecifc T cell population responding to a transplanted organ consists of both naive and memory lymphocytes. Although it is established that naive T cells are activated by antigen within the organized structures of secondary lymphoid organs (the spleen, lymph nodes, and mucosal lymphoid tissues), it is not clear whether memory T cell activation and propagation depend on homing to these o...

Chronic rejection triggers the development of an aggressive intragraft immune response through recapitulation of lymphoid organogenesis.

The unwarranted persistence of the immunoinflammatory process turns this critical component of the body's natural defenses into a destructive mechanism, which is involved in a wide range of diseases, including chronic rejection. Performing a comprehensive analysis of human kidney grafts explanted because of terminal chronic rejection, we observed that the inflammatory infiltrate becomes organiz...

TLR-induced local metabolism of vitamin D3 plays an important role in the diversification of adaptive immune responses.

The addition of monophosphoryl lipid A, a minimally toxic derivative of LPS, to nonmucosally administered vaccines induced both systemic and mucosal immune responses to coadministered Ags. This was dependent on an up-regulated expression of 1alpha-hydroxylase (CYP27B1, 1alphaOHase), the enzyme that converts 25-hydroxycholecalciferol, a circulating inactive metabolite of vitamin D(3), into 1,25(...